Wave Life Sciences stock hits a 52-week low at USD 4.20

Wave Life Sciences Ltd. (SG1V20936237) traded as low as USD 4.20 on Nasdaq on September 22, 2026, setting a new 52-week low before last trading at USD 4.26. The price was down from the prior close of USD 4.35, while volume reached 2,372,427 shares.

Revenue misses estimates

The latest reported quarter remains the central operating reference. According to MarketBeat on September 22, 2026, Wave reported revenue of USD 2.27 million for the quarter announced on July 30, 2026, compared with analyst estimates of USD 7.45 million. The shortfall was USD 5.18 million, or about 69.5 percent below the estimate.

The same July 30, 2026 quarterly report showed a loss of USD 0.34 per share, versus consensus for a loss of USD 0.30 per share, according to MarketBeat. The reported loss was USD 0.04 per share worse than the consensus estimate, adding pressure to a share price already near its annual low.

Management adds a business chief

Wave announced the appointment of Dr. Monika Vnuk as chief business officer on September 22, 2026. According to GlobeNewswire, the company published the appointment and provided investor-relations contacts for the announcement.

The timing puts management development beside the more difficult earnings comparison. A revenue result of USD 2.27 million against USD 7.45 million expected is a concrete gap of USD 5.18 million, while the USD 0.34 quarterly loss per share exceeded the expected loss by USD 0.04.

Price remains below consensus value

MarketBeat reported on September 22, 2026, that the stock had a consensus rating of Moderate Buy and a consensus price target of USD 22.31. That target is USD 18.05 above the last traded price of USD 4.26, although the article does not identify an individual analyst house or provide a target-change history.

The market capitalization was USD 839.43 million on September 22, 2026, and the price-to-earnings ratio was negative 3.91, according to the same market update. The negative ratio reflects reported losses rather than a conventional earnings valuation.

Stock closes near yearly low

Wave Life Sciences stock last traded at USD 4.26 on Nasdaq on September 22, 2026, after reaching USD 4.20 during the session. The prior close was USD 4.35, making the intraday last price USD 0.09 below that reference level.

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